Natural History and Patient Journey in Atrial Fibrillation: a Nationwide Linked Electronic Health Records Study of 5.6 Million Individuals.

• Conditions: Epidemiology; Atrial Fibrillation

• Registration Number: NCT04786366
• Lead Sponsor: University College, London

Brief Summary

The trajectory of atrial fibrillation (AF) patients within the national health system and their recent temporal trends remains to be fully elucidated. To study the AF incidence, mortality and case-fatality, the investigators implemented a longitudinal cohort study with the linked electronic health records of 5.6 million population in the UK from 1998 to 2016 (CALIBER). A matched case-control study design was used to investigate the causes of hospitalization and death comparing individuals with and without incident AF.

Detailed Description

Not available

Study Timeline

• Study Start: 1998-01-01
• Primary Completion: 2016-05-31
• Study First Submitted: 2020-12-04
• Status Verified: 2021-03
• Study First Submitted QC: 2021-03-03
• Last Update Submitted: 2021-03-03
• Study First Posted: 2021-03-08
• Last Update Posted: 2021-03-08
• Study Completion: 2021-06-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 5601803

Inclusion Criteria

• The investigators identify individuals aged 18 years or older and registered in the current primary care practice for at least one year.

Exclusion Criteria

• Individuals are excluded if they had a prior history of AF before study entry.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Incidence of Atrial fibrillation	Jan 1st 1998 - May 31st 2016	AF incidence in the population
Mortality of Atrial fibrillation	Jan 1st 1998 - May 31st 2016	Mortality among AF patients