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Clinical Trials/ISRCTN29863839
ISRCTN29863839
Completed
未知

A prospective, randomised, controlled trial to evaluate the efficacy and safety of endoscopic choroid plexus coagulation with third ventriculostomy in the treatment of idiopathic Normal Pressure Hydrocephalus

The Frenchay Hydrocephalus Research Fund (UK)0 sites0 target enrollmentOctober 17, 2002
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Conditionsormal Pressure Hydrocephalus (NPH)Nervous System DiseasesNormal Pressure Hydrocephalus (NPH)

Overview

Phase
未知
Intervention
Not specified
Conditions
ormal Pressure Hydrocephalus (NPH)
Sponsor
The Frenchay Hydrocephalus Research Fund (UK)
Status
Completed
Last Updated
9 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
October 17, 2002
End Date
TBD
Last Updated
9 years ago
Study Type
Interventional
Sex
All

Investigators

Sponsor
The Frenchay Hydrocephalus Research Fund (UK)

Eligibility Criteria

Inclusion Criteria

  • •1\. A clinical diagnosis of Normal Pressure Hydrocephalus (NPH) by the following criteria:
  • •a. Evidence of significant gait disturbance in the absence of other causative factors
  • •b. Evidence of some cognitive impairment on formal neuropsychological testing (Mattis dementia rating scale and Folstein mini\-mental state examination) and/or urinary incontinence or evidence of neurogenic urinary disturbance (frequency or urgency)
  • •c. Lumbar Opening Pressure less than 20 mmHg on supine lumbar puncture
  • •2\. Symptom duration of more than six months
  • •3\. Evidence of disease progression since onset of symptoms
  • •4\. Radiological evidence of hydrocephalus, Evans ratio more than 0\.3 on Computed Tomography (CT) scan of head
  • •5\. Patients must be fit enough to undergo operative surgical treatment, as defined by an American Society of Anesthesiologists (ASA) score of one, two or three
  • •6\. Written informed consent to participation in the study obtained from the patient, or next of kin if the patient is unable (due to cognitive impairment) to give informed consent

Exclusion Criteria

  • •Not provided at time of registration

Outcomes

Primary Outcomes

Not specified

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