Comparison Of Efficacy Of Levosimendan Versus Milrinone In Catecholamine Resistant Septic Shock With Myocardial Dysfunction In Children : A Single-Center, Open-Label Randomized controlled Trial

1. Patients presenting to Paediatric department of AIIMS Patna (meeting inclusion criteria) will be randomly allocated in 1:1 ratio to two independent treatment groups using opaque sealed envelope method:

Group A: Receives  levosimendan as an  ionodilator drug therapy

Group B: Receives  milrinone  as an ionodilator  drug therapy

After sample selection as per inclusion criteria after randomization children were started on either milrinone or levosimendan. As levosimendan is in powder form, it will be diluted in 5ml normal saline (standard dilution) to make clear fluid. Milrinone is available as clear fluid and both of these drug is stable for more than 24 hours at room temperature when given as an infusion However if shock persists after the study protocol treating team may further decide the use of any inotrope as open label as per type of shock & clinical profile of the patient using their description