Thromboelastography During Surgery for Malignant Pleural Mesothelioma
- Conditions
- CoagulopathyMesothelioma
- Interventions
- Procedure: Blood draw for TEG analysis
- Registration Number
- NCT01912547
- Lead Sponsor
- Brigham and Women's Hospital
- Brief Summary
Surgery for malignant pleural mesothelioma is complex and prolonged, and may involve significant blood loss with considerable blood and product transfusion. Thromboelastography (TEG) is a global assay of coagulation that uses whole blood to produce a tracing that records kinetic changes in clot formation. This study aims provide a better understanding of the coagulation profile of these patients, and will form the basis of a TEG-based transfusion algorithm for future surgeries for mesothelioma.
- Detailed Description
Thromboelastography can provide more in-depth and quicker analysis of the complex coagulation processes during surgery
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 100
- Adult male or female patients undergoing elective surgery for malignant pleural mesothelioma
- Unwilling or unable to provide consent
- History of bleeding disorder
- On medications that may affect hemostasis
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Blood draw for TEG analysis Blood draw for TEG analysis TEG analysis of blood from patients at different points in time
- Primary Outcome Measures
Name Time Method Coagulation profile during extrapleural pneumonectomy or pleurectomy Surgical period (4-6 hours) Reaction time, alpha angle, maximum amplitude and clot lysis from thromboelastography give a better picture of coagulation at different phases of surgery
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Brigham and Women's Hospital
🇺🇸Boston, Massachusetts, United States