The Effects of Low-dose Atropine and Orthokeratology in Pediatric Myopia Control
- Conditions
- Myopia
- Interventions
- Device: orthokeratologyDrug: low-dose atropine eye drops
- Registration Number
- NCT05478356
- Lead Sponsor
- Evidence Based Cataract Study Group
- Brief Summary
Both orthokeratology and atropine eye drops are effective methods for myopia control, but few studies have compared them all together simultaneously. Therefore, the primary aim of the present study was to compare the effect of orthokeratology versus low-dose (0.01% and 0.02%) atropine on the control of myopia progression.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 100
Best corrected visual acuity less then 0.00 log MAR (minimum angle of resolution) units Cycloplegic SER of - 1.0 D or less in both eyes. An inter-eye cycloplegic SER difference of 1.00 D or more.
Children with cycloplegic cylinder refraction of more than + 1.00 D or less than - 1.00 D.
History of binocular vision problems, including strabismus. History of known ocular disorders, including media opacities, macular dysgenesis, optic nerve hypoplasia, perinatal brain injury, buphthalmos, and retinopathy of prematurity.
History of medication use that might have affected the refractive results. Systemic or developmental problems that might have hindered refractive development.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description orthokeratology group orthokeratology - low-dose atropine group low-dose atropine eye drops -
- Primary Outcome Measures
Name Time Method Progression of myopia 1 year The change of myopia (Ds)
Progression of axial length 1 year The change of axial length (mm)
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
Visionly Eye Hospital
🇨🇳Beijing, Beijing, China
Parkway Hospital
🇨🇳Shanghai, Shanghai, China