When Should Carbetocin be Administered to Prevent Postpartum Hemorrhage After Normal Vaginal Delivery?
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- Carbetosin effect
研究概览
简要总结
Postpartum haemorrhage (PPH) is one of the major contributors to maternal mortality and morbidity worldwide. Active management of the third stage of labour has been proven to be effective in the prevention of PPH. Syntometrine is more effective than oxytocin but is associated with more side effects. Carbetocin, a long-acting oxytocin agonist, appears to be a promising agent for the prevention of PPH. The use of carbetocin, being an important agent in the prevention of PPH, also increases its prevalence. It is planned to investigate the advantages and disadvantages of the timing of its use.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Singleton pregnancy
- •Vaginal delivery at or beyond 38 weeks of gestation
排除标准
- •Multiparity
- •Contraindications to carbetocin use (e.g., pre-existing hypertension, pre-eclampsia,asthma, cardiac, renal, or liver disease)
- •High-risk factors for primary postpartum hemorrhage, including grand multiparity,presence of uterine fibroids, or a need for prophylactic oxytocin infusion
- •Anemia or
- •body mass index (BMI) over 35
- •Baby weight over 4000 grams
- •Comorbidities or chronic diseases
- •History of curettage
- •Use of propess or oxytocin during labor
结局指标
主要结局
Carbetosin effect
时间窗: 24 hours after delivery
incidence of postpartum hemorrhage \>500 ml (percent (%)), additional uterotonics using (yes/no), placenta retention (yes/no), adverse effects (hypotension (yes/no), tachycardia (yes/no), headache(yes/no) oliguria (yes/no)),
次要结局
未报告次要终点
研究者
Mehmet Mete Kırlangıç
Dr. Lütfi Kırdar Kartal Eğitim ve Araştırma Hastanesi
Dr. Lutfi Kirdar Kartal Training and Research Hospital