The Combination Therapy of Fractional Laser and PRP Compared With Nanofat Grafting and PRP Synergy in Treating Striae Gravidarum.
- Conditions
- Treatments of Striae Gravidarum
- Interventions
- Device: Fractional CO2 LaserProcedure: Nanofat graftingProcedure: Platelet-rich plasma (PRP) Injection
- Registration Number
- NCT03328871
- Lead Sponsor
- First Affiliated Hospital of Jinan University
- Brief Summary
Nowadays, multiple treatment modalities have been applied clinically to treat striae gravidarum, such as laser therapy, microdermabrasion, platelet-rich plasma injection(PRP), etc. To some extent, these treatments can improve striae gravidarum. In this clinical trial, the investigators are going to treat striae gravidarum by using two different kinds of combination therapies. One is fractional laser and PRP injection synergy, and the other one is treated by nanofat grafting with PRP injection.
- Detailed Description
The investigators will pick out two areas of most severe striae gravidarum on a participant's abdomen. One of the areas will be treated by fractional laser once every three months for 2 times combined with PRP injection once a month for 6 times. Another area will be treated by nanofat grafting once every three months for 2 times and PRP therapy once a month for 6 times. The participants were asked to come back 1、3、6、9 months after treatment for further follow-up.
Before and after the treatment, the striae gravidarum will be assessed subjectively by satisfaction assessment, dermatoscope and ultrasound, and objectively by immunohistochemical analysis.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 10
- The striae gravidarum was appeared within 3 years
- Age ≤ 35 years old
- Not in lactation
- Not pregnancy within one year
- Skin allergy
- Skin inflammation or wound
- Platelet dysfunction syndrome
- Take anticoagulant drugs
- Acute or chronic infection
- Chronic liver disease
- Photodermatosis
- Active vitiligo, psoriasis, systemic lupus erythematosus
- Other clinical trial
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SEQUENTIAL
- Arm && Interventions
Group Intervention Description Fractional CO2 Laser and PRP injection Fractional CO2 Laser One of the striae gravidarum areas will be treated by fractional laser once every three months for 2 times combined with PRP injection once a month for 6 times. Nanofat grafting and PRP injection Platelet-rich plasma (PRP) Injection Another area will be treated by nanofat grafting once every three months for 2 times and PRP therapy once a month for 6 times. Nanofat grafting and PRP injection Nanofat grafting Another area will be treated by nanofat grafting once every three months for 2 times and PRP therapy once a month for 6 times. Fractional CO2 Laser and PRP injection Platelet-rich plasma (PRP) Injection One of the striae gravidarum areas will be treated by fractional laser once every three months for 2 times combined with PRP injection once a month for 6 times.
- Primary Outcome Measures
Name Time Method Immunohistochemical analysis Baseline and 15 months. The tissue extracted will be taken for immunohistochemical analysis to observe the change of epidermal and dermal thickness, and the distribution and amount of elastic fiber and collagen fiber,etc.
- Secondary Outcome Measures
Name Time Method Ultrasound Baseline and at 3,6,9,12,15 months after the treatments. The striae gravidarum will be assessed by ultrasound in order to observe the change of dermal thickness of striae after the application of laser or nanofat grafting with PRP injection.
Dermatoscope Baseline and at 3,6,9,12,15 months after the treatments. The striae gravidarum will be assessed by dermatoscope to observe the pigmentation condition of striae after the application of laser or nanofat grafting with PRP injection.
Trial Locations
- Locations (1)
First Affiliated Hospital of Jinan University
🇨🇳Guangzhou, Guangdong, China