Biomarkers of Acrylamide, Glycidol, POPs, PFAS and Disease Outcomes and OMICs Signatures
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 9,254
- 主要终点
- Cardiovascular disease
研究概览
简要总结
The aim of the project is to assess the associations between biomarkers of acrylamide and glycidol exposure and disease outcomes in a case-cohort study based on two prospective cohorts with biobanks. The investigators also aim to assess the exposure-affected OMICS signatures and molecular pathways underlying disease development (specifically cardiovascular diseases such as myocardial infarction and stroke and cancer such as breast-, endometrial and colorectal cancer) for these exposures along with persistent organic pollutants (POPs) and per- and polyflouroalkyl substances (PFAS) using a prospective cohort study utilizing and integrating various 'OMICs' technologies.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •60YO: Men and women of 60 years old residing in Stockholm
- •SMC-C: Women residing in Uppsala
排除标准
- •Subjects will be excluded if they had the outcome under investigation at baseline
结局指标
主要结局
Cardiovascular disease
时间窗: From baseline beginning in 2003 through 2017
Using International Classification of Diseases (ICD) codes to assess cardiovascular disease (CVD) incidence (myocardial infarction and stroke, ICD10: I21 and I63)
Cancer
时间窗: From baseline (2003 for SMC-C and 1997 for 60YO) until the latest available follow-up, currently 2021
Using ICD codes to assess cancer (such as ICD-10: C18, C20, C50, C54)
次要结局
未报告次要终点
研究者
Agneta Åkesson
Professor
Karolinska Institutet