Incidences of hereditary diffuse gastric cancer, CDH1 germline mutation, gastric cancer and breast cancer : A single center prospective observational study
Not Applicable
Recruiting
- Conditions
- Neoplasms
- Registration Number
- KCT0007455
- Lead Sponsor
- Asan Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 430
Inclusion Criteria
Patients who have histologically confirmed diffuse gastric cancer.
Patients meeting Hereditary Diffuse Gastric Cancer genetic testing criteria of 2020 International Gastric Cancer Linkage Consortium
Exclusion Criteria
Gastric cancer other than diffuse type
Remnant gastric cancer
Recurred gastric cancer
History of previous gastrectomy
History of any malignancy within recent 5 years (Except for Lobular breast cancer)
Presence of severe comorbidity (e.g. cardiac, hepatic, or renal insufficiency) or coagulopathy
Pregnant or lactating women
Presence of psychiatric disorder that may preclude compliance
Patients who cannot understand informed consent
Study & Design
- Study Type
- Observational Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of genetic mutation
- Secondary Outcome Measures
Name Time Method Incidences of gastric and breast cancer within the family of patients with hereditary diffuse gastric cancer