Effects of NAVA and PSV to AECOPD Patients' Air Distribution and Dead Space
Phase 3
- Conditions
- Chronic Obstructive Pulmonary Disease
- Interventions
- Device: NAVA and PSV
- Registration Number
- NCT02289573
- Lead Sponsor
- Southeast University, China
- Brief Summary
Chronic obstructive pulmonary disease(COPD) is a common disease among people. Acute exacerbation of chronic obstructive pulmonary disease(AECOPD) is the acute and aggravating phase of COPD which may lead to respiratory failure. Mechanical ventilation is a very important therapy for those patients,but traditional ventilation modes have some defects, so investigators need to find new modes to solve these problems. In this study, the investigators compare neurally adjusted ventilatory assist (NAVA) and PSV to observe the effects on AECOPD patients' air distribution and dead space to determine if NAVA is a more appropriate ventilation mode for AECOPD patients.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 15
Inclusion Criteria
- AECOPD patients who need invasive mechanical ventilation
- Patients who can tolerate assist mechanical ventilation
- Patients who have signed ICF
Exclusion Criteria
- Patients who are younger than 18 years old or older than 75 years old
- Patients whose respiratory center is severely inhibited
- Patients who can not stand NAVA gastric tube
- Patients who have coagulation disorders
- Patients whose vital signs are unstable
- Patients who are in other clinical trails
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description neurally adjusted ventilatory assist NAVA and PSV - pressure support ventilation NAVA and PSV -
- Primary Outcome Measures
Name Time Method the ratio of physiologic dead space over tidal volume (VD/VT) 1 year
- Secondary Outcome Measures
Name Time Method