Effects of NAVA and PSV to AECOPD Patients' Air Distribution and Dead Space
试验速览
- 阶段
- 3 期
- 发起方
- 入组人数
- 15
- 主要终点
- the ratio of physiologic dead space over tidal volume (VD/VT)
研究概览
简要总结
Chronic obstructive pulmonary disease(COPD) is a common disease among people. Acute exacerbation of chronic obstructive pulmonary disease(AECOPD) is the acute and aggravating phase of COPD which may lead to respiratory failure. Mechanical ventilation is a very important therapy for those patients,but traditional ventilation modes have some defects, so investigators need to find new modes to solve these problems. In this study, the investigators compare neurally adjusted ventilatory assist (NAVA) and PSV to observe the effects on AECOPD patients' air distribution and dead space to determine if NAVA is a more appropriate ventilation mode for AECOPD patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •AECOPD patients who need invasive mechanical ventilation
- •Patients who can tolerate assist mechanical ventilation
- •Patients who have signed ICF
排除标准
- •Patients who are younger than 18 years old or older than 75 years old
- •Patients whose respiratory center is severely inhibited
- •Patients who can not stand NAVA gastric tube
- •Patients who have coagulation disorders
- •Patients whose vital signs are unstable
- •Patients who are in other clinical trails
结局指标
主要结局
the ratio of physiologic dead space over tidal volume (VD/VT)
时间窗: 1 year
次要结局
未报告次要终点
研究者
Jianfeng Xie
MD
Southeast University, China