Thrombus Imaging and Treatment Analytics in Neurology

Recruiting

• Conditions: Thrombus, Brain; Thrombosis

• Registration Number: NCT05663281
• Lead Sponsor: Chinese PLA General Hospital

Brief Summary

In the present study, the investigators use high-resolution MR vessel wall imaging, and select patients with cerebral and cervical artery occlusion to investigate the relationship between the imaging appearance of thrombus and the various outcome of recanalization treatment.

Detailed Description

Cerebral ischemic stroke resulting from thrombosis causes high disability and mortality. There are few biomarkers to evaluate arterial thrombophilia until now. Previous studies have demonstrated that atherosclerotic plaque rupture and erosion are major etiologies initiating thrombosis. Based on previous works targeting the role of plaque and blood flow in cerebrovascular disease, in the present study, the investigators use high-resolution MR vessel wall imaging, and select patients with cerebral and cervical artery occlusion to explore the relationship between the imaging appearance of thrombus and the various outcome of recanalization treatment. The study's objective was to solve the challenges in the mechanism of thrombus features and the outcome of recanalization therapy, thus helping improve the primary and secondary prevention of cerebrovascular disease.

Study Timeline

• Study Start: 2022-12-15
• Study First Submitted: 2022-12-15
• Study First Submitted QC: 2022-12-15
• Study First Posted: 2022-12-23
• Status Verified: 2024-06
• Last Update Submitted: 2024-06-30
• Last Update Posted: 2024-07-03
• Primary Completion: 2027-12-31
• Study Completion: 2027-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Age ≥ 18 years
• Extracranial and/or intracranial artery occlusion confirmed by angiography
• Available for magnetic resonance high-resolution vessel wall imaging
• Written informed consent obtained

Exclusion Criteria

• Extracranial and/or intracranial artery mild to moderate stenosis
• Pregnant women
• Restenosis or occlusion after artery stenting placement

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Ischemic Stroke Occurrence	1-3 Years	Ischemic stroke occurrence during follow-up period which was confirmed by neuroimaging
Rate of Successful Recanalization	1-3 Years	Antegrade blood flow through the recanalized portion was assessed by thrombolysis in myocardial infarction (TIMI) score or thrombolysis in cerebral infarction (TICI) score. TIMI≥2 or TICI≥2b was defined as successful recanalization.

Secondary Outcome Measures

Name	Time	Method
Number of Participants with Adverse Events	1-3 Years	hemorrhagic or ischemic stroke after recanalization treatment

Trial Locations

Locations (1)

Chinese PLA General Hospital; 🇨🇳 Beijing, Beijing, China