Evaluation of Two Different Grafting Techniques After Mandibular Impacted Third Molar Surgery

Not Applicable

• Conditions: Periodontal Pocket; Impacted Third Molar Tooth; Impacted Teeth With Abnormal Position
• Interventions: Procedure: Impacted third molar surgery; Procedure: Application of mineralised plasmatic matrix; Procedure: Application of β-tricalcium phosphate

• Registration Number: NCT04366635
• Lead Sponsor: Konya Necmettin Erbakan Üniversitesi

Brief Summary

This study evaluates the effectiveness of using Mineralized Plasmatic Matrix and β-tricalcium phosphate that placed to extraction socket as a graft material in terms of periodontal damage occurred in the distal aspect of the second molar after mandibular impacted third molar surgery.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-04-26
• Study First Submitted QC: 2020-04-26
• Study Start: 2020-04-27
• Study First Posted: 2020-04-29
• Status Verified: 2020-05
• Last Update Submitted: 2020-05-04
• Last Update Posted: 2020-05-06
• Primary Completion: 2020-05-20
• Study Completion: 2020-08-20

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• Medically healthy.
• Periodontally healthy patients.
• Patients with mesioangular or horizontal impacted teeth that will cause periodontal damage at the distal part of the second molar after surgery.

Exclusion Criteria

• Crowns on second molar teeth.
• Poor oral hygiene.
• Patients with a systemic disease affecting periodontal healing.
• Pregnancy or lactation period.
• Patients undergoing orthodontic treatment.
• Smokers.
• The cases where the buccal or lingual cortical bone didn't remain intact following the extraction were also excluded.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Mineralised Plasmatic Matrix Group	Application of mineralised plasmatic matrix	Mineralized Plasmatic Matrix (MPM) is a product of mixing of two phases: the mineral phase and the plasma phase. After centrifugation, the white blood cells are recovered and mixed with the mineral phase of bone graft that can be autogenic, allogeneic bone, or a bone substitute like Xenogeneic Bone Synthetic. We will use Beta-tricalcium phosphate as a graft material. The result of this mixture is a homogeneous single component, which is compact and stable, containing the graft, the dense fibrin network, and the promoting healing. And then we are planning to place MPM material to extraction socket of impacted third molar tooth to improve periodontal healing at the distal aspect of second molar tooth. Additional after MPM places to extraction socket, Once the MPM has been placed, it will be covered with a Platelet Rich Fibrin (PRF) membrane and sutured as a primer.
Beta-tricalcium phosphate Group	Application of β-tricalcium phosphate	Beta-tricalcium phosphate graft will place in the extraction socket and cover with a PRF membrane.
Beta-tricalcium phosphate Group	Impacted third molar surgery	Beta-tricalcium phosphate graft will place in the extraction socket and cover with a PRF membrane.
Control Group	Impacted third molar surgery	In the control group, after removal of impacted third molar tooth no material will be placed on the extraction socket. Only the extraction socket was primarily closed with non-resorbable sutures.
Mineralised Plasmatic Matrix Group	Impacted third molar surgery	Mineralized Plasmatic Matrix (MPM) is a product of mixing of two phases: the mineral phase and the plasma phase. After centrifugation, the white blood cells are recovered and mixed with the mineral phase of bone graft that can be autogenic, allogeneic bone, or a bone substitute like Xenogeneic Bone Synthetic. We will use Beta-tricalcium phosphate as a graft material. The result of this mixture is a homogeneous single component, which is compact and stable, containing the graft, the dense fibrin network, and the promoting healing. And then we are planning to place MPM material to extraction socket of impacted third molar tooth to improve periodontal healing at the distal aspect of second molar tooth. Additional after MPM places to extraction socket, Once the MPM has been placed, it will be covered with a Platelet Rich Fibrin (PRF) membrane and sutured as a primer.

Primary Outcome Measures

Name	Time	Method
Periodontal pocket depth	At 0 day	Initial periodontal pocket depth measurement at the distal aspect of second molar tooth before extraction.
Alveolar bone level	At 0 day	Initial bone level measurement at the distal aspect of second molar tooth before extraction.

Secondary Outcome Measures

Name	Time	Method
Periodontal pocket depth	At 6th month	Secondary measurement of periodontal pocket depth after extraction
Alveolar bone level	At 6th month	Secondary measurement of bone level after extraction

Trial Locations

Locations (1)

Necmettin Erbakan University, Faculty of dentistry; 🇹🇷 Konya, Turkey