PREdicting Failure of Non-inVasIve Ventilatory Support Using Non-invaSIve mONitoring in Non-intubated Patients With Acute Hypoxemic Respiratory Failure or Post-extubation Failure: the PREVISION Study

简要总结

详细描述

This is a single-center, prospective, physiological study. The study will enroll patient who has used either HFNC or NIV for the indications of 1. to prevent worsening acute hypoxemic respiratory failure or 2. to prevent reintubation. Once being confirmed to meet the inclusion criteria, the research team will apply the electrical impedance tomography (EIT) on the patient and start recording for 5-10 minutes as well as perform diaphragm and parasternal intercostal muscle ultrasound when the patient is using HFNC or NIV. The current HFNC or NIV setting, some lung mechanic's parameters (e.g. rapid shallow breathing trial (RSBI), negative airway pressure generated during the first 100 milisecond (P0.1), end-expiratory occlusion pressure(ΔPocc) derived from NIV machine), patient's characteristic, dyspnea scores (intensive care respiratory distress observation scale, IC-RDOS; work of breathing scale; self-report of dyspnea visual analog scale, D-VAS), ICU and hospital length of stay will be also collected. The investigator will use EIT to visualize where air goes in the patient's lung and inspiratory muscle ultrasonography (diaphragm and parasternal intercostal muscle) to visualize the muscle activities when using HFNC or NIV. EIT is a measurement often used in the ICU since it allows easy visualization and is a non-invasive technique. The sensors measure electrical current changes during inspiration and expiration and will not cause any pain or radiation concerns. The EIT belt (3-cm diameter) will be placed around the chest without causing adverse event/discomfort/pain. The duration of study will be approximately 30 minutes. The study will be conducted one time for one enrolled patient. HFNC or NIV (device) failure is considered as either intubation/reintubation or death, whatever has come first. It will be followed up to 7 days. The investigators will proceed with the measurements only with agreement from the clinical team. The investigators will analyze the data collected offline with a dedicated software afterwards. After these study procedures are completed, data will also be collected from the participant's chart and combined with relevant information from the HFNC or NIV settings and vital functions. Confidentiality will be maintained throughout the entire study.

主要结局

次要结局

• Diaphragm or parasternal intercostal muscle thickening fraction(The parameter is measured at the time of enrolment. Failure of HFNC or NIV is adjudicated at 7 days.)
• Rapid shallow breathing index (RSBI) in mL/breaths/min(The parameter is measured at the time of enrolment. Failure of HFNC or NIV is adjudicated at 7 days.)
• Respiratory drive using negative airway pressure generated during the first 100 millisecond (P0.1)(The parameter is measured at the time of enrolment. Failure of HFNC or NIV is adjudicated at 7 days.)
• Respiratory effort using end-expiratory airway occlusion pressure (ΔPocc)(The parameter is measured at the time of enrolment. Failure of HFNC or NIV is adjudicated at 7 days.)
• The intensive care respiratory distress observation scale (IC-RDOS)(The parameter is measured at the time of enrolment. Failure of HFNC or NIV is adjudicated at 7 days.)
• The work of breathing scale(The parameter is measured at the time of enrolment. Failure of HFNC or NIV is adjudicated at 7 days.)
• Self-report of dyspnea visual analog scale (D-VAS)(The parameter is measured at the time of enrolment. Failure of HFNC or NIV is adjudicated at 7 days.)