A RANDOMIZED, PARALLEL GROUP, OPEN LABEL, ACTIVE CONTROLLED CLINICAL STUDY TO COMPARE THE SAFETY AND EFFICACY OF A TOPICAL UNANI FORMULATION WITH ADAPALENE (0.1 percent) IN THE MANAGEMENT OF BUTHUR LABANIYYA (ACNE VULGARIS)

Overall prevalence of Acne worldwide consists of 20.5%.The Prevalence was highest among the age group 16 to 24, reaching 28.4%. Drugs used in conventional medicines are effective, but these drugs are associated with multiple side effects. Keeping all these facts in consideration, Keeoing all these facts in considerations, A topical Unani Formulation given byHakeem Mohammad Azam Khan (1814-1902), for Buthur Labaniyyais used for this clinical trial. This Randomized, Active controlled, Parallel Group, Open Label, Clinical study has planned to evaluate the Efficacy and Safety of a Topical Unani Formulation in the management of acne vulgaris. Participants fulfilling inclusion and exclusion criteria will be receive either test or control drug as per randomization, in test group participants will be receive Topical Unani Formulation as ointment for local application once daily at affected sites as per requirement, in control drug participants will be given Adapalene 0.1% gel topically once daily at affected sites as per requirement.  Laboratory investigation will be done at baseline and last follow up. Duration of the study is 4 weeks. For  statistical analysis Student t test will be used to find the statistically significant difference in the parameters within the group/ inter the group.  All the result analysis will be done using MS excel 2019.