Comparison of the effect of Intrauterine Platelet Rich Plasma instillation to oestradiol valerate alone in infertile women with thin endometrium undergoing Ovarian Stimulation: An Open Labelled Randomised Control Trial

Thin endometrium is a significant barrier to successful implantation in infertile women undergoing ovarian stimulation. Endometrial thickness (ET) less than 7 mm is associated with reduced pregnancy rates. Conventional treatment includes estradiol valerate; however, recent studies suggest intrauterine Platelet Rich Plasma (PRP) may enhance endometrial growth and vascularity. This open-labelled randomized controlled trial aims to compare the effects of PRP instillation combined with estradiol valerate versus estradiol valerate alone in infertile women with thin endometrium. The primary objective is to assess changes in ET and endometrial vascularity, while secondary outcomes include pregnancy and live birth rates. The study involves 56 participants randomized into two groups, with pre- and post-intervention ultrasound assessments. If effective, PRP could become a recommended adjunct in thin endometrium management.