Improvement of Liver Function in Liver Cirrhosis Patients After Autologous Mesenchymal Stem Cell Injection:a Phase I-II Clinical Trial

Phase 1

Completed

• Conditions: Liver Failure; Cirrhosis

• Registration Number: NCT00420134
• Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary

The methods for separation of mesenchymal stem cell were established in 2001. These cells can differentiate to osteocytes, hepatocytes, chondrocytes, myocytes and etc,. In this study the investigators try to separate mesenchymal stem cell from end stage liver disease, then these cells will be differentiated to progenitor of hepatocytes, finally , the investigators injected these cells into portal vein under ultrasound guide. The investigators determine the effects of injected cells in reestablishment of liver function.

Detailed Description

Not available

Study Timeline

• Study Start: 2006-02
• Study First Submitted: 2007-01-08
• Study First Submitted QC: 2007-01-08
• Study First Posted: 2007-01-09
• Primary Completion: 2009-05
• Study Completion: 2009-06
• Status Verified: 2009-09
• Last Update Submitted: 2009-09-15
• Last Update Posted: 2009-09-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Liver function test
MELD score

Secondary Outcome Measures

Name	Time	Method
Cirrhosis mortality after 6 months

Trial Locations

Locations (2)

Research center of Gastroenterology and Liver Disease; 🇮🇷 Tehran, Iran, Islamic Republic of

Research Center for Gastroenterology and Liver Diseases; 🇮🇷 Tehran, Iran, Islamic Republic of