Effect of Timolol on Refractive Outcomes in Eyes With Myopic Regression After LASIK: a Randomized Clinical Trial
- Registration Number
- NCT01506635
- Lead Sponsor
- Shahid Beheshti University of Medical Sciences
- Brief Summary
In this randomized controlled clinical trial, we compare the effects of timolol versus placebo for treatment of myopic regression after LASIK
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 45
Inclusion Criteria
- Patients with myopic regression equal or more than 0.5 D with minimum age of 20 years,
- cylinder ≤ -1.00 D,
- corrected distance visual acuity (CDVA) of at least 20/40 were included.
Exclusion Criteria
- Patients with a history of previous ocular surgery,
- keratoconus or any ectatic corneal disorder,
- keratoconus suspect by topography,
- preoperative corneal opacity,
- any corneal dystrophies,
- presence of pterygium,
- retinal disorders,
- collagen vascular disorders,
- diabetes mellitus,
- glaucoma,
- cataract,
- pregnancy,
- breast feeding
- systemic corticosteroid therapy were excluded.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Control group Placebo included patients who received artificial tear twice a day as control group. Timolol group Timolol included the patients with myopic regression who received timolol 0.5% eye drop twice a day
- Primary Outcome Measures
Name Time Method Spherical Equivalent spherical equivalent at month 6 Effect of timolol use in timolol group will be compared with placebo group at month 6. Moreover, the changes of intragroup spherical equivalent will be assessed in both group 6 months after timolol application.
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Ophthalmic Research Center
🇮🇷Tehran, Iran, Islamic Republic of