Effect of Surgical Therapy on RANKL/OPG (Osteoprotegerin) System

Completed

• Conditions: RANKL/OPG Ratio; Aggressive Periodontitis; Chronic Periodontitis; Gingival Crevicular Fluid

• Registration Number: NCT02190773
• Lead Sponsor: Hacettepe University

Brief Summary

In the present clinical study including chronic, aggressive periodontitis and healthy individuals, the investigators aimed to determine the RANKL, osteoprotegrin (OPG), Interleukin-1 (IL-1β), IL-10, IL-1β levels in gingival crevicular fluid(GCF) before and after surgical periodontal treatment and search out the relationship of clinical parameters with these cytokine levels.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-01
• Primary Completion: 2013-04
• Study Completion: 2013-04
• Status Verified: 2014-07
• Study First Submitted: 2014-07-08
• Study First Submitted QC: 2014-07-13
• Last Update Submitted: 2014-07-13
• Study First Posted: 2014-07-15
• Last Update Posted: 2014-07-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 65

Inclusion Criteria

• Chronic periodontitis having at least 5mm or more probing depth and aggressive periodontitis patients.

Exclusion Criteria

• Any known systemic disorder, used antibiotics and/or anti-inflammatory medications, had periodontal treatment in the last 3 months and all of them were non smokers. Subjects who were lactating and pregnant were also excluded.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
RANKL/OPG ratio	Baseline - 3months	RANKL/OPG ratio changes 3 months after surgical periodontal treatment in Chronic and Aggressive periodontitis
OPG level (pg) in GCF	Baseline-3 months	Changes in OPG levels 3 months after surgical periodontal treatment in Chronic and Aggressive periodontitis determined by ELISA
RANKL (pmol) level in GCF	Baseline-3 months	Changes in RANKL levels 3 months after surgical periodontal treatment in Chronic and Aggressive periodontitis determined by ELISA

Secondary Outcome Measures

Name	Time	Method
IL-1β (pg) levels in GCF	Baseline, 3 months after treatment	Changes in IL-1β levels (determined by ELISA) 3 months after surgical periodontal treatment in Chronic and Aggressive Periodontitis groups
Il-10 (pg) levels in GCF	Baseline-3 months	Changes in IL-10 levels (determined by ELISA) 3 months after surgical periodontal treatment in Chronic and Aggressive periodontitis

Trial Locations

Locations (1)

Hacettepe University; 🇹🇷 Ankara, Turkey