Effect of Surgical Periodontal Therapy on the RANKL/OPG System : Do we Need Osteo-immune Modulation Targeting RANKL?
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Chronic Periodontitis
- Sponsor
- Hacettepe University
- Enrollment
- 65
- Locations
- 1
- Primary Endpoint
- OPG level (pg) in GCF
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
In the present clinical study including chronic, aggressive periodontitis and healthy individuals, the investigators aimed to determine the RANKL, osteoprotegrin (OPG), Interleukin-1 (IL-1β), IL-10, IL-1β levels in gingival crevicular fluid(GCF) before and after surgical periodontal treatment and search out the relationship of clinical parameters with these cytokine levels.
Investigators
Ezel Berker
Ezel Berker
Hacettepe University
Eligibility Criteria
Inclusion Criteria
- •Chronic periodontitis having at least 5mm or more probing depth and aggressive periodontitis patients.
Exclusion Criteria
- •Any known systemic disorder, used antibiotics and/or anti-inflammatory medications, had periodontal treatment in the last 3 months and all of them were non smokers. Subjects who were lactating and pregnant were also excluded.
Outcomes
Primary Outcomes
OPG level (pg) in GCF
Time Frame: Baseline-3 months
Changes in OPG levels 3 months after surgical periodontal treatment in Chronic and Aggressive periodontitis determined by ELISA
RANKL (pmol) level in GCF
Time Frame: Baseline-3 months
Changes in RANKL levels 3 months after surgical periodontal treatment in Chronic and Aggressive periodontitis determined by ELISA
RANKL/OPG ratio
Time Frame: Baseline - 3months
RANKL/OPG ratio changes 3 months after surgical periodontal treatment in Chronic and Aggressive periodontitis
Secondary Outcomes
- IL-1β (pg) levels in GCF(Baseline, 3 months after treatment)
- Il-10 (pg) levels in GCF(Baseline-3 months)