The Effect of Prefrontal Cortex Stimulation on Antisocial and Aggressive Behavior

Not Applicable

Completed

• Conditions: Antisocial Behavior; Aggression
• Interventions: Device: Sham transcranial direct current stimulation; Device: Transcranial direct current stimulation

• Registration Number: NCT02427672
• Lead Sponsor: University of Pennsylvania

Brief Summary

This study investigates the effect of upregulating prefrontal cortex activity on antisocial and aggressive behavior and risk factors for such behavior. In the double-blind, randomized controlled trial, participants will undergo anodal transcranial direct current stimulation bilaterally to the dorsolateral prefrontal cortex or a sham stimulation. During and after stimulation, they will complete survey and laboratory measures assessing antisocial and aggressive behavior and risk factors for antisocial and aggressive behavior. Heart rate and skin conductance will also be measured.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-03
• Study First Submitted: 2015-03-26
• Study First Submitted QC: 2015-04-22
• Study First Posted: 2015-04-28
• Primary Completion: 2017-12
• Study Completion: 2018-12
• Results First Submitted: 2019-02-22
• Status Verified: 2019-08
• Results First Submitted QC: 2019-08-14
• Last Update Submitted: 2019-08-14
• Results First Posted: 2019-08-28
• Last Update Posted: 2019-08-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 84

Inclusion Criteria

• Above 18 years of age
• Able to understand the nature of the study and give informed consent

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Exclusion Criteria

• History of or active neurologic, cardiovascular, or psychiatric disease
• Currently consuming anti-convulsant, anti-psychotic, or sedative/hypnotic medications
• Currently consuming anti-depressants
• History of seizures
• Metallic implants on the scalp
• Participation in other transcranial magnetic stimulation (TMS) or tDCS experiments on the same day
• History of adverse reactions to tDCS

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Sham stimulation	Sham transcranial direct current stimulation	The sham transcranial direct current stimulation condition will involve the same placement of the electrodes, current intensity, and ramp time as the real tDCS condition, but stimulation will only last for 30 seconds.
Anodal stimulation	Transcranial direct current stimulation	Participants in the active stimulation group will undergo anodal bilateral transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex. tDCS will be delivered by a battery-driven, constant-current stimulator connected to three saline-soaked surface sponge electrodes. Two anodal electrodes (25cm2) will be placed over the dorsolateral prefrontal cortex bilaterally and one cathodal electrode (35cm2) will be placed at the back of the neck. Scalp electrodes will be positioned over the F3 and F4 according to the 10-20 EEG international system. A current of 1mA will be applied for 20 minutes and the current will be ramped up and down at the beginning and end of the stimulation period.

Primary Outcome Measures

Name	Time	Method
Change in Antisocial Behavior Inclinations at 24 Hours	Baseline (an average of 15 minutes before receiving tDCS or sham) and on average, 24 hours following stimulation or sham	This will be assessed using hypothetical scenarios in which someone commits a criminal or antisocial act. The two brief scenarios describe a physical assault and a sexual assault. Participants will respond to the likelihood that they would commit the act in the scenario according to a 10-point Likert scale. Responses were measured on a scale ranging from zero (no chance at all) to ten (100 percent chance). Scores for both scenarios were summed to obtain an overall measure of intentions to commit aggression. Possible scores range from 0 to 20. A higher value indicates a greater inclination to engage in the antisocial act.
Number of Pins Inserted Into a Virtual Voodoo Doll at 24 Hours	On average, 24 hours after the tDCS or sham session	The number of pins (between 0 and 51) that participants decide to insert into a picture of a voodoo doll on a computer that represents either a romantic partner or close friend will be recorded on average 24 hours after receiving tDCS or sham stimulation.

Trial Locations

Locations (1)

University of Pennsylvania; 🇺🇸 Philadelphia, Pennsylvania, United States