ISRCTN34420460已完成2 期
A Randomised phase II multi-centre Trial of topical treatment in women with Vulval Intraepithelial Neoplasia (TR3-VIN)
Cardiff University (UK)0 个研究点目标入组 180 人开始时间: 2007年9月25日最近更新:
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 180
研究概览
简要总结
2014 Results article in http://www.ncbi.nlm.nih.gov/pubmed/25304851 results 2018 Results article in https://www.ncbi.nlm.nih.gov/pubmed/29336101 long-term follow-up results (added 05/08/2019)
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- Female
入选标准
- •1. Women with biopsy proven Vulval Intraepithelial Neoplasia 3 (VIN3) (including visible peri-anal disease not extending into the anal canal)
- •2. At least one lesion of sufficient size to allow biopsies (greater than or equal to 1 cm2)
- •3. Informed consent
排除标准
- •1. Any patients with impaired renal function
- •2. Any patient with current anogenital carcinoma or any patient who, in the investigators opinion, is at a high risk of developing invasive disease (patients in whom invasive or microinvasive disease is suspected should have adequate biopsies to exclude this prior to entry)
- •3. Pregnancy, breast feeding or trying to conceive
- •4. Active treatment for VIN within the previous four weeks
- •5. Patients who are under 18 years old
- •6. Known allergy to either of the topical treatments
- •7. Unable to comply with protocol treatment
- •8. Prior failure of imiquimod or cidofovir following treatment 3 times a week for a minimum of 12 weeks
研究者
相似试验
已完成
2 期
Thykamine Safety and Efficacy Study in Mild-to-Moderate Atopic DermatitisAtopic Dermatitis EczemaNCT03540043PurGenesis Technologies Inc.162
已完成
2 期
stekinumab in adolescents with recent-onset type 1 diabetesNutritional, Metabolic, EndocrineType 1 diabetes mellitusISRCTN14274380Cardiff University88
已完成
2 期
Study of the effectiveness of the addition of Capecitabine to a standard regimen containing Adriamycin®, Cyclophosphamide and Docetaxel as neoadjuvant treatment in large or locally advanced breast cancersarge or locally advanced breast cancerMalignant neoplasm of breastCancerISRCTN00407556nited Lincolnshire Hospitals NHS Trust (UK)130
已完成
2 期
Cediranib maleate with or without gefitinib in treating patients with recurrent or progressive glioblastomaCancerISRCTN00549973niversity College London (UK)38
已完成
3 期
A multicentre, phase III, randomised, double-blind, placebo-controlled trial of pravastatin added to first-line chemotherapy in patients with small cell lung cancerLung cancerSmall cell lung cancerCancerISRCTN56306957niversity College London (UK)860