Drug-drug interaction study to assess the effects of administration of K-237 on the pharmacokinetics of digoxin or rosuvastatin in healthy adult volunteers (COVID-19)

Kowa Company, Ltd.0 个研究点目标入组 10 人开始时间: 2022年7月11日最近更新: 2023年9月8日

试验速览

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•(1) Subject is a healthy adult male volunteer.
•(2) Subject is between the ages of 18 and 45 years at the time of signing informed consent.
•(3) Subject has a body mass index of 17.6 to 26.4 kg/m2 at Screening.

•(1) Subject has used a drug (including over-the-counter drug, vaccination) within 14 days before the administration of the study drug in the first treatment period, or those who need to use it during the study period.
•(2) Subject has received products containing St John's wort within 4 weeks before the administration of the study drug in the first treatment period. Subject has received supplements and products containing grapefruit within 14 days before the administration of the study drug in the first treatment period.
•(3) Subject has a current malabsorption, and those who had an operation on the gastrointestinal tract that may affect absorption (excluding appendectomy).

Plasma pharmacokinetic parameters

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发起方