Could Tai-chi Help Maintain Balance of Spinocerebellar Ataxia Patients

Not Applicable

Completed

• Conditions: Spinocerebellar Ataxias; Tai Chi
• Interventions: Behavioral: Tai chi; Drug: conventional medicine

• Registration Number: NCT03687190
• Lead Sponsor: Changhua Christian Hospital

Brief Summary

Spinocerebellar atrophy is the most common autosomal dominant inherited ataxia. There are over thirty subtypes, which characterize neurologic features differently. They all have obvious substantial cerebellar atrophies in image, and unstable gait、ataxia. In general a prevalence of about three cases per 100 000 people is assumed, but this may be an underestimate. Progressive neurologic degeneration, in about 10-20 years, will leads to disability or wheelchair-dependent. Accompanying with fatigue, downhill course of the disease often made patients depressive and hopeless. The recent review of researches concludes no effective therapy for the disease. The purpose of the investigator's study is to explore the Tai-chi exercise effect for spinocerebellar ataxia.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-05-13
• Primary Completion: 2015-12-02
• Study Completion: 2015-12-02
• Study First Submitted: 2018-09-26
• Study First Submitted QC: 2018-09-26
• Study First Posted: 2018-09-27
• Results First Submitted: 2021-10-22
• Results First Submitted QC: 2021-11-28
• Results First Posted: 2022-01-27
• Status Verified: 2023-08
• Last Update Submitted: 2023-08-29
• Last Update Posted: 2023-08-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

• progressive ataxia accompanied with the observation of cerebellar atrophy on magnetic resonance or computed tomography images
• SARA score of less than 20

Exclusion Criteria

• Patients with complicated cerebellar disorders, such as multiple system atrophy, Parkinson-plus syndromes, secondary cerebellar degeneration from encephalitis, trauma, hypoxia, cerebrovascular diseases, and toxic- or drug-induced cerebellar degeneration
• SARA score of larger than 20

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Tai chi	Tai chi	participants in this group accepted Tai chi exercise and conventional medicine.
Tai chi	conventional medicine	participants in this group accepted Tai chi exercise and conventional medicine.
controlled group	conventional medicine	participants were not received Tai chi exercise, but only routine conventional medicine

Primary Outcome Measures

Name	Time	Method
Scale for the Assessment and Rating of Ataxia(SARA)	assessed at baseline and 9 months, 9 months reported as Outcome Measure Data	SARA assesses eight aspects of cerebellar function: walking, sitting, standing, speaking, finger chasing, the nose-finger test, fast alternating hand movements, and the heel-shin slide. The eight categories accumulate score ranging from 0 (no ataxia) to 40 (most severe ataxia).Gait (0-8 points),Stance (0-6 points),Sitting (0-4 points),Speech disturbance (0-6 points),Finger chase (0-4 points),Nose-finger test (0-4 points),Fast alternating hand movement (0-4 points),Heel-shin slide (0-4 points)