Integrative Medicine and Tai-chi in Clinical Status of Spinocerebellar Ataxia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 21
- 主要终点
- Scale for the Assessment and Rating of Ataxia(SARA)
研究概览
简要总结
Spinocerebellar atrophy is the most common autosomal dominant inherited ataxia. There are over thirty subtypes, which characterize neurologic features differently. They all have obvious substantial cerebellar atrophies in image, and unstable gait、ataxia. In general a prevalence of about three cases per 100 000 people is assumed, but this may be an underestimate. Progressive neurologic degeneration, in about 10-20 years, will leads to disability or wheelchair-dependent. Accompanying with fatigue, downhill course of the disease often made patients depressive and hopeless. The recent review of researches concludes no effective therapy for the disease. The purpose of the investigator's study is to explore the Tai-chi exercise effect for spinocerebellar ataxia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •progressive ataxia accompanied with the observation of cerebellar atrophy on magnetic resonance or computed tomography images
- •SARA score of less than 20
排除标准
- •Patients with complicated cerebellar disorders, such as multiple system atrophy, Parkinson-plus syndromes, secondary cerebellar degeneration from encephalitis, trauma, hypoxia, cerebrovascular diseases, and toxic- or drug-induced cerebellar degeneration
- •SARA score of larger than 20
研究组 & 干预措施
Tai chi
participants in this group accepted Tai chi exercise and conventional medicine.
干预措施: Tai chi (Behavioral)
Tai chi
participants in this group accepted Tai chi exercise and conventional medicine.
干预措施: conventional medicine (Drug)
controlled group
participants were not received Tai chi exercise, but only routine conventional medicine
干预措施: conventional medicine (Drug)
结局指标
主要结局
Scale for the Assessment and Rating of Ataxia(SARA)
时间窗: assessed at baseline and 9 months, 9 months reported as Outcome Measure Data
SARA assesses eight aspects of cerebellar function: walking, sitting, standing, speaking, finger chasing, the nose-finger test, fast alternating hand movements, and the heel-shin slide. The eight categories accumulate score ranging from 0 (no ataxia) to 40 (most severe ataxia).Gait (0-8 points),Stance (0-6 points),Sitting (0-4 points),Speech disturbance (0-6 points),Finger chase (0-4 points),Nose-finger test (0-4 points),Fast alternating hand movement (0-4 points),Heel-shin slide (0-4 points)
次要结局
未报告次要终点
研究者
Chiu Chung Min
Adjunct Physician
Changhua Christian Hospital