Evaluation the effect of 24 -hour moisturizers
Phase 2
Recruiting
- Conditions
- Dry skin.
- Registration Number
- IRCT20190210042676N4
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
Male or female aged 18-60 years
The presence of skin dryness
Voluntary participation and signing written informed consent
Exclusion Criteria
Active skin diseases
Active smoking
Pregnancy or breastfeeding
Using systemic corticosteroid in the past 30 days
Use of any topical drugs in the past 7 days
Scar, wound or any condition on the inner forearms that could interfere with a clear-cut assessment of the skin
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Comparison the change in stratum corneum hydration after using two types of moisturizers and cream base formulation. Timepoint: Before intervention and 1 and 4 hours, 24 h, 2weeks after using and one week after not using. Method of measurement: Corneometry.
- Secondary Outcome Measures
Name Time Method Aquaporin 3 (AQP3) mRNA level. Timepoint: After two weeks application. Method of measurement: Real time PCR.;Trans Epidermal Water Loss. Timepoint: Before intervention and 1 and 4 hours, 24 h, 2weeks after using and one week after not using. Method of measurement: Tewameter.;Skin elasticity. Timepoint: Before intervention and 1 and 4 hours, 24 h, 2weeks after using and one week after not using. Method of measurement: Cutometery.