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临床试验/NCT05707923
NCT05707923招募中不适用

How Single-Word and Telegraphic Simplification Affects Language Processing and Word Learning in Young Children With Autism Spectrum Disorder

Michigan State University2 个研究点 分布在 1 个国家目标入组 104 人开始时间: 2023年6月1日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
入组人数
104
试验地点
2
主要终点
Gaze location on Looking-While-Listening (LWL) tasks

研究概览

简要总结

The long-term study goal is to experimentally evaluate the components (and likely active ingredients) of early language interventions for young children with ASD. The overall objective is to determine how single-word and telegraphic simplification affects real-time language processing and word learning in young children with ASD (relative to full, grammatical utterances). The proposed project will investigate three specific aims: 1) Determine how single-word and telegraphic simplification affects language processing. 2) Determine how single-word and telegraphic simplification affects word learning. 3) Evaluate child characteristics that may moderate the effects of linguistic simplification on language processing and word learning. Aim 1 will test the hypothesis that children with ASD will process full, grammatical utterances faster and more accurately than single-word or telegraphic utterances. Aim 2 will test the hypothesis that full, grammatical utterances will support word learning better than telegraphic or single-word utterances. Aim 3 will test the hypothesis that language and cognitive skills significantly moderate the effects of linguistic simplification on language processing and word learning in young children with ASD.

研究设计

研究类型
Interventional
分配方式
Na
干预模型
Single Group
主要目的
Treatment
盲法
None

入排标准

年龄范围
1 Year 至 4 Years(Child)
性别
All
接受健康志愿者

入选标准

  • Existing or suspected autism spectrum disorder, confirmed through ADOS-2
  • English as primary language
  • 1-4 years old

排除标准

  • Known genetic condition (e.g., Down syndrome, fragile X)
  • Cerebral palsy
  • Acquired brain injury
  • Uncorrected vision or hearing impairment

结局指标

主要结局

Gaze location on Looking-While-Listening (LWL) tasks

时间窗: Single assessment per task; total duration less than 10 minutes per task

LWL involves a child looking at a screen with two images, one on each side of the screen, while being provided an auditory cue that includes the name of the target image. The primary outcome is a dichotomous variable indicating whether the child is fixated on the target image or the distracter image; gaze directed at neither image will be considered missing. It will be determined whether gaze is to the left or right image, using trained coders who are blind to target side. Gaze location will be observed every 33 ms from 300 ms after onset to 2000 ms after target word onset, for a total of 51 observations per trial. Analyses will focus on differences across trial types and child characteristics in the trajectory of gaze location over the course of the trial.

次要结局

  • Gaze location in Teaching Phase of Study 2b (Fast Mapping)(Single assessment; total duration less than 10 minutes)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Courtney E. Venker

Assistant Professor

Michigan State University

研究点 (2)

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