The Performance of Renal Doppler Ultrasound in Predicting Outcome of Dialysis Weaning
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Acute Kidney Injury
- Sponsor
- Johan Fridolf Hermansen
- Enrollment
- 33
- Locations
- 1
- Primary Endpoint
- Dialysis weaning
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
Acute kidney injury (AKI) is a frequent problem in the intensive care unit (ICU) affecting more than 50 % of patients. AKI is associated with several adverse outcomes, including increased mortality and increased length of ICU- and hospital stay, in particular in patients requiring Renal Replacement Therapy (RRT).
Choosing the optimal time for attempting liberation from RRT is still unclear. With this study, we will describe the ability of renal ultrasound in predicting the outcome of dialysis weaning.
Investigators
Johan Fridolf Hermansen
Principal Investigator
Aarhus University Hospital
Eligibility Criteria
Inclusion Criteria
- •All patients ≥ 18 years admitted to the ICU, Aarhus University Hospital who are treated with dialysis as continuous renal placement therapy (CRRT) and planned to undergo dialysis weaning
Exclusion Criteria
- •Insufficient ultrasonographic imaging of the kidneys
- •Known morphological kidney disease
- •Previous need of chronic RRT
- •Prior participation in the study
- •Need of extracorporeal membrane oxygenation (ECMO) or other heart assist device
Outcomes
Primary Outcomes
Dialysis weaning
Time Frame: 7 days
If discontinuation of Dialysis is successful or not. Successful dialysis weaning is defined as no renal replacement therapy (RRT) required within the first 7 days after stopping continuous renal replacement therapy (CRRT) and non-successful weaning as the need for RRT within the first 7 days.
Secondary Outcomes
- Renal Doppler arterial Resistive Index (RI)(Measured at the beginning of weaning and after 6 hours.)
- Renal Doppler Venous Impedance Index (VII)(Measured at the beginning of weaning and after 6 hours.)
- Portal vein Doppler Pulsatility Fraction PF)(Measured at the beginning of weaning and after 6 hours.)
- Urine Output(4 days)
- Renal Doppler Renal Venous Stasis Index (RVSI)(Measured at the beginning of weaning and after 6 hours.)
- Urine Creatinine Clearance(4 days)