Azole Susceptibility and Resistance Mechanisms Surveys in Pathogenic Fungi by the China Antifungal Resistance Surveillance Trial (CARST)-Fungi (2023-2024)
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- The type and spectrum of azole-resistance in the pathogenic fungi
研究概览
简要总结
The China Antifungal Resistance Surveillance Trial (CARST-fungi) study, which has been starting in July 2019, is a multi-center, prospective, observational, and laboratory-based study of pathogenic fungal isolates causing IFDs. All fungal isolates recovered from clinical samples will be collected. For each episode of fungal isolation, the information including the patient's age, gender, the ward location, the time of sample collection, and specimen type will be collected. All isolates will be sent to the Research Center for Medical Mycology, Beijing, China, for further study including species identification and azole susceptibility testing. Azole-resistant mechanisms will be elucidated by gene sequencing or expression level assay for resistance-related genes.
详细描述
Invasive fungal diseases (IFDs) are life-threatening diseases with considerable morbidity and mortality, primarily occurring in immunocompromised and critically ill hosts. Azoles represent the most widely prescribed antifungal class for IFDs. However, azole-resistance has become a growing problem worldwide. The major resistance mechanisms include mutations or overexpression of the drug target gene ERG11/cyp51, and overexpression of drug efflux pumps. Different resistance mechanisms vary by species and geographic distribution, and the underlying mechanisms in some species have not been well defined. A better understanding of antifungal resistance mechanisms will provide insights to reclaim those antifungal drugs as an option for empiric treatment of IFDs. Thus, comprehensive survey of azole susceptibility and resistance mechanisms of pathogenic fungi plays a significant role in understanding epidemiology and antifungal susceptibility such that to guide empirical therapy and aid antifungal stewardship efforts.
Since antifungal susceptibilities of pathogenic fungi are changing gradually year by year, the investigator put forward the following objectives and hypotheses of our survey:
Objectives
- To survey azole-susceptibility status and evolutionary trend of pathogenic fungi isolated from tertiary hospitals in China
- To elucidate the mechanisms and characteristics of azole-resistance in different pathogenic fungi
Hypotheses
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Other
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •fungal disease
排除标准
- •non-fungal disease
结局指标
主要结局
The type and spectrum of azole-resistance in the pathogenic fungi
时间窗: By the end of Dec. 2025
次要结局
未报告次要终点