Incidence of Acute Pulmonary Embolism in Covid-19 Patients on CT Angiography and Relationship to D-dimer Levels

Completed

• Conditions: Covid-19 With Positive RT-PCR

• Registration Number: NCT04373486
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

Reports of acute pulmonary embolism (APE) associated with COVID-19 have emerged in the literature. For example, Chen et al. described 25 pulmonary CT angiograms examinations from 1008 COVID-19 patients; 10 were positive for pulmonary embolism mostly as segmental or sub-segmental APE. Case reports of APE in Covid-19 patients have been published. Cui et al. found an incidence of deep venous thrombosis in intensive care unit (ICU) patients with severe Covid-19 pneumonia near to 25% (20/81), however without any correlation with potential APE.

Despite these initial reports, it is not clear whether APE is more frequent in Covid-19 patients or if the association is just random. In favor of the former, D-dimer levels have been reported as elevated in patients with Covid-19 by two studies, and it has been suggested an independent association between the severity of the disease and the level of D-dimer. Finally, Tang et al. showed that anticoagulant therapy is associated with a decreased mortality at Day-28 in severe Covid-19 patients, in favor of a possible associated coagulopathy. The purpose of this study is to describe the rate of pulmonary embolus in patients classified as COVID-19 infection and who underwent chest CT angiography.

The purpose of this study is to describe the rate of pulmonary embolus in patients classified as COVID-19 infection and who underwent chest CT angiography.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-03-03
• Status Verified: 2020-04
• Primary Completion: 2020-04-30
• Study First Submitted: 2020-04-30
• Study First Submitted QC: 2020-04-30
• Study Completion: 2020-05-01
• Study First Posted: 2020-05-04
• Last Update Submitted: 2021-01-08
• Last Update Posted: 2021-01-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 160

Inclusion Criteria

• Positive SARS-Cov-2 RT-PCR
• Chest CT angiography available
• Patient is aged 18yo or above

Exclusion Criteria

• Expressed opposition to participate
• Adults under guardianship

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Rate of positivity for Acute Pulmonary Embolism	March 1, 2020 - March 31, 2020

Trial Locations

Locations (1)

Service de Radiologie B - NHC; 🇫🇷 Strasbourg, France