Dual-Energy CT on Plan Quality, Dose-delivery Accuracy, and Simulated Outcomes of Patients Treated With Proton or Photon Therapy

Not Applicable

Terminated

• Conditions: Brain Cancer; Head and Neck Cancer; Lung Cancer
• Interventions: Device: Siemens Somatom Definition Edge; Device: Philips Brilliance Big Bore CT/simulator

• Registration Number: NCT03403361
• Lead Sponsor: Washington University School of Medicine

Brief Summary

The aim of this protocol is to refine the accuracy of proton beam therapy (PT) by the use of dual energy computed tomography (DECT), in conjunction with novel iterative image reconstruction algorithms, to more precisely determine the tissue properties through which the proton beam path travels.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2018-01-11
• Study First Submitted QC: 2018-01-11
• Study First Posted: 2018-01-18
• Study Start: 2018-06-01
• Primary Completion: 2022-08-11
• Study Completion: 2022-08-11
• Disposition First Submitted: 2023-06-16
• Disposition First Posted: 2023-07-25
• Status Verified: 2024-02
• Results First Submitted: 2024-02-03
• Results First Submitted QC: 2024-02-03
• Last Update Submitted: 2024-02-03
• Results First Posted: 2024-03-01
• Last Update Posted: 2024-03-01

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

• Diagnosis of histologically proven primary or metastatic cancer requiring thoracic radiation therapy OR radiation therapy to the head and neck or brain
• At least 18 years of age.
• Planning to undergo proton or photon beam radiation therapy as part of the clinical management of the diagnosed cancer.
• Able to understand and willing to sign an IRB-approved written informed consent document.

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Exclusion Criteria

• Implanted metallic objects in the region to be scanned excepting dental prostheses
• IV or oral contrast medium within 24 hours prior to DECT image acqusition
• Pregnant.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Dual-Energy CT scan	Philips Brilliance Big Bore CT/simulator	Patients enrolling in this study will undergo additional sequential DECT scan in addition to their routine SECT or DECT scan.
Dual-Energy CT scan	Siemens Somatom Definition Edge	Patients enrolling in this study will undergo additional sequential DECT scan in addition to their routine SECT or DECT scan.

Primary Outcome Measures

Name	Time	Method
Dose Difference in 99% Planning Target Volume (PTV) Coverage Between Single Energy CT and Dual Energy CT	Day 1

Trial Locations

Locations (1)

Washington University School of Medicine; 🇺🇸 Saint Louis, Missouri, United States