Dual-Energy CT on Plan Quality, Dose-delivery Accuracy, and Simulated Outcomes of Patients Treated With Proton or Photon Therapy
Not Applicable
Terminated
- Conditions
- Brain CancerHead and Neck CancerLung Cancer
- Registration Number
- NCT03403361
- Lead Sponsor
- Washington University School of Medicine
- Brief Summary
The aim of this protocol is to refine the accuracy of proton beam therapy (PT) by the use of dual energy computed tomography (DECT), in conjunction with novel iterative image reconstruction algorithms, to more precisely determine the tissue properties through which the proton beam path travels.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 36
Inclusion Criteria
- Diagnosis of histologically proven primary or metastatic cancer requiring thoracic radiation therapy OR radiation therapy to the head and neck or brain
- At least 18 years of age.
- Planning to undergo proton or photon beam radiation therapy as part of the clinical management of the diagnosed cancer.
- Able to understand and willing to sign an IRB-approved written informed consent document.
Exclusion Criteria
- Implanted metallic objects in the region to be scanned excepting dental prostheses
- IV or oral contrast medium within 24 hours prior to DECT image acqusition
- Pregnant.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Dose Difference in 99% Planning Target Volume (PTV) Coverage Between Single Energy CT and Dual Energy CT Day 1
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Washington University School of Medicine
🇺🇸Saint Louis, Missouri, United States
Washington University School of Medicine🇺🇸Saint Louis, Missouri, United States