NL-OMON42624尚未招募3 期
Venlafaxine for prevention of oxaliplatin-induced peripheral neuropathy - A randomised clinical trial - VENLOX
试验速览
- 阶段
- 3 期
- 状态
- 尚未招募
- 入组人数
- 150
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •24 years or older
- •Oxaliplatin based chemotherapy, XELOX regimen (with or without bevacizumab)
- •Performance state of at least 2 (ECOG) or 60 (Karnofsky)
- •Written informed consent
排除标准
- •Participating in other clinical trial (eg CAIRO 4 or Orchestra studies in
- •colorectal carcinoma patients)
- •Brain or leptomeningeal metastasis
- •Previous treatment with platinum based chemotherapy
- •Alcohol addiction
- •(Pre)existing neuropathy
- •Use of anti-epileptics, anti-depressants, anti-retroviral drugs, MAO-inhibitors or lithium.
- •Use of strong enzyme modulating drugs (CYP2D6): fluoxetine, bupropion, kinidine, paroxetine or ritonavir
- •Psychologically instable, psychiatric disorder
- •Known allergy for venlafaxine
- •Pregnancy or breast feeding
研究者
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