HLA Sensitization in Severely Burned Patients

• Conditions: Severely Burned Patients

• Registration Number: NCT02537821
• Lead Sponsor: University of Zurich

Brief Summary

Primary goal of this study is the analysis of HLA (Human leucocyte antigen) formation in severly burned patients. Potential HLA triggers in the treatment of severely burned patients are blood products, assist devices or temporary allogeneic skin. Besides that, inflammatory markers, such as WBC (white blood cell count), CRP (C-reactive protein), PCT (Procalcitonin) and two novel biomarkers (PSP (pancreatic stone protein), ST2) are to be investigated in severely burned patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2015-06
• Study First Submitted: 2015-07-01
• Study First Submitted QC: 2015-08-28
• Study First Posted: 2015-09-02
• Status Verified: 2017-11
• Last Update Submitted: 2017-11-20
• Last Update Posted: 2017-11-21
• Primary Completion: 2018-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• severely burned patients in need for hospitalization

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Exclusion Criteria

• hematologic diseases
• Cancer

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
HLA antibody formation (HLA Sensitization) (Unit: PRA in %)	Change from Baseline (admission) in HLA antibody count at 2 weeks, 4 weeks, 3 months and 6 months	The degree of sensitization is reported as the percentage of CDC (Complement dependent Cytotoxicity) Panel Reactive Antibody (PRA). Unit is %.

Trial Locations

Locations (1)

University Hospital Zurich; 🇨🇭 Zurich, Switzerland