HLA Sensitization in Severely Burned Patients
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- HLA antibody formation (HLA Sensitization) (Unit: PRA in %)
研究概览
简要总结
Primary goal of this study is the analysis of HLA (Human leucocyte antigen) formation in severly burned patients. Potential HLA triggers in the treatment of severely burned patients are blood products, assist devices or temporary allogeneic skin. Besides that, inflammatory markers, such as WBC (white blood cell count), CRP (C-reactive protein), PCT (Procalcitonin) and two novel biomarkers (PSP (pancreatic stone protein), ST2) are to be investigated in severely burned patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •severely burned patients in need for hospitalization
排除标准
- •hematologic diseases
结局指标
主要结局
HLA antibody formation (HLA Sensitization) (Unit: PRA in %)
时间窗: Change from Baseline (admission) in HLA antibody count at 2 weeks, 4 weeks, 3 months and 6 months
The degree of sensitization is reported as the percentage of CDC (Complement dependent Cytotoxicity) Panel Reactive Antibody (PRA). Unit is %.
次要结局
未报告次要终点