NCT00164801TerminatedNot Applicable
Is Visceral Hyperalgesia the Culprit of Noncardiac Chest Pain in Chinese? Part 2: Effect of GABAB Agonist on Visceral Hyperalgesia in NCCP Patients
Chinese University of Hong Kong1 site in 1 country60 target enrollmentStarted: November 1, 2004Last updated:
Conditions
Drugs
Trial Snapshot
- Phase
- Not Applicable
- Status
- Terminated
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Esophageal sensory and pain thresholds
Study Overview
Brief Summary
The effect of baclofen (GABAB agonist), diltiazem (muscle relaxant) and placebo will be compared in a double-blinded randomized study for the treatment of NCCP. Cerebral cortical, brainstem and spinal evoked potentials before and after treatment will be evaluated. Results of this study will shed lights on pathogenesis and treatment of NCCP in Chinese.We hypothesize that Baclofen alleviates visceral hyperalgesia in NCCP patients by suppressing afferent sensory pathway.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Double
Eligibility Criteria
- Ages
- 18 Years to 70 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Consecutive patients with monthly angina-like chest pain and negative coronary angiogram or scintigraphy
- •Age between 18-70
- •Gastroesophageal reflux disease
- •Psychiatric illness
- •Cerebrovascular accident
- •Active peptic ulceration
- •Heart failure or cardiac bradyarrhythmia
- •Pregnancy or lactating female
- •Previous hypersensitivity to muscle relaxant
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Esophageal sensory and pain thresholds
Secondary Outcomes
- Symptom severity of chest pain at the end of treatment
- Evoked potential responses
Investigators
Study Sites (1)
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