NCT00164801终止不适用
Is Visceral Hyperalgesia the Culprit of Noncardiac Chest Pain in Chinese? Part 2: Effect of GABAB Agonist on Visceral Hyperalgesia in NCCP Patients
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Esophageal sensory and pain thresholds
研究概览
简要总结
The effect of baclofen (GABAB agonist), diltiazem (muscle relaxant) and placebo will be compared in a double-blinded randomized study for the treatment of NCCP. Cerebral cortical, brainstem and spinal evoked potentials before and after treatment will be evaluated. Results of this study will shed lights on pathogenesis and treatment of NCCP in Chinese.We hypothesize that Baclofen alleviates visceral hyperalgesia in NCCP patients by suppressing afferent sensory pathway.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Consecutive patients with monthly angina-like chest pain and negative coronary angiogram or scintigraphy
- •Age between 18-70
- •Gastroesophageal reflux disease
- •Psychiatric illness
- •Cerebrovascular accident
- •Active peptic ulceration
- •Heart failure or cardiac bradyarrhythmia
- •Pregnancy or lactating female
- •Previous hypersensitivity to muscle relaxant
排除标准
- 未提供
结局指标
主要结局
Esophageal sensory and pain thresholds
次要结局
- Symptom severity of chest pain at the end of treatment
- Evoked potential responses
研究者
研究点 (1)
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