Cognitive impairment following cardiac arrest and Target Temperature Management (A sub-study of the TTM Trial)

Completed

Conditions: cognitive disorders
memory and concentration disturbances
10057167

Registration Number: NL-OMON36855

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 85

Inclusion Criteria

1. TTM study patients who are alive at six-month follow-up and give consent to the cognitive sub-study
2. Informants (usually a relative or close friend/caregiver) of the patient above (1) who give consent to the cognitive sub-study
3. STEMI patients at the given centre, the sex-matched patient who best fits in age to the TMM patient above (1) with a similar date of infarct who gives consent to the cognitive sub-study
4. Informants (usually a relative or close friend/caregiver) of 3 above who give consent to participate.

Exclusion Criteria

The same exclusion criteria as for the main TTM study with the addition that control patients should not have a history of cardiac arrest.
Exclusion criteria TTM study: Conscious patients, pregnancy, out-of-hospital cardiac arrest of presumed non-cardiac cause, cardiac arrest after arrival in hospital, known bleeding diathesis, suspected or confirmed acute intracranial bleeding, suspected or confirmed acute stroke, temperature on admission <30°C, unwitnessed asystole, persistent cardiogenic shock, known limitations in therapy, known disease making 180 day survival unlikely, known pre-arrest cerebral performance category 3 or 4, >240 minutes from ROSC to randomisation, no informed consent.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Comparing scores on cognitive test scales between patients after cardiac arrest<br /><br>treated with 33 or 36 degrees and patients after myocardial infarction.</p><br>

Secondary Outcome Measures