To study efficacy of Bramhi Ghrita in Mild Cognitive Impairment (Smrutimandya/ memory loss )

Phase 1

Not yet recruiting

Conditions: Mild intellectual disabilities. Ayurveda Condition: MANOVAHASROTOVIKARAH,

Brief Summary: Mild Cognitive Impairment (MCI )is the most commonly observed disease amongst elderly people and it is responsible for developing the diseases like Dementia and Alzheimerâ€™s disease(AD) (1) MCI is the most important stage between normal ageing and dementia. Prevalence of MCI observed globally is 15.56%(2). The high conversion rate from MCI to AD places a large burden on individual and family. Thus, it is a need of time to pay attention to the treatment of MCI. Comorbidities especially Hypertension and Diabetes aggravates MCI in elderly people therefore it needs to get controlled.

According to Sharangadhara Acharya, Medha (grasping and retention power) starts declining after the fourth decade of life and this may be considered as an alarming signal for further decline of Smriti (memory) and Buddhi (intellect), in the successive years. Rasayana Chikitsa has a major role to play in this arena. Nootropic drugs like Guduchi, Ashwagandha, Brahmi, Shankhapushpi various ghritas have proven efficacy in cognitive domains of psychological wellbeing. Brahmi being the most effective and safe drug is chosen for the present study in the form of Brahmi Ghrita

Recruitment & Eligibility

Inclusion Criteria

Exclusion Criteria

1. Known case of Dementia, Alzheimerâ€™s disease 2) Patients with evidence of delirium and other disturbances of consciousness 3) Patients having complications of major illness such as Liver/Kidney failure 4) Known case of Encephalopathy, Epileptic attacks, Coagulopathies, Neuromuscular diseases, Cancer, Stroke, intracranial hemorrhage, brain tumors and brain surgeries.
1. Patients using any type of psychotropic drugs.
1. Uncontrolled DM(HbA1C> 7.5) and its complications 7) Uncontrolled HTN (Systolic >160 &Diastolic>100) and itâ€™s complications 8) Immunocompromised patients 9) patients having Hb<8 g/dl 10) Patients having Dyslipidemia especially Sr Cholesterol >220 mg/dl, Sr Triglycerides > 180 mg/dl, Sr LDL > 150 mg/dl.
1. BMI > 40 and < 18 12) Patients with physical impairment, such as walking, sitting, bladder and bowel incontinence.

Primary Outcome Measures

Name	Time	Method
1) To evaluate efficacy of Brahmi Ghrita in Mild Cognitive impairment (MCI) in Elderly people.	1 week, 4 week, 8 week , 12 week

Secondary Outcome Measures

Name	Time	Method
to study adverse drug reaction if any	3 months

Locations (1): PDEAs Ayurved Rugnalaya and Sterling Multispecialty Hospital Pune
🇮🇳
Pune, MAHARASHTRA, India
PDEAs Ayurved Rugnalaya and Sterling Multispecialty Hospital Pune
🇮🇳Pune, MAHARASHTRA, India
Dr Rupali Tarachand Khobragade
Principal investigator
8378929859
khobragaderupali19@gmail.com