The Effect of Dexmedetomidine for Emergence Cough

Not Applicable

Completed

• Conditions: Cough
• Interventions: Drug: Dexmedetomidine; Drug: Remifentanil; Drug: Normal saline

• Registration Number: NCT03622502
• Lead Sponsor: Ajou University School of Medicine

Brief Summary

Dexmedetomidine or remifentanil are effective in attenuating cough during peri-extubation period after general anesthesia. The purpose of this study was to investigate the effect of dexmedetomidine on the remifentanil concentration for the cough suppression during anesthetic emergence.

Detailed Description

Administration of dexmedetomidine before end of surgery could reduce airway reflexes and hemodynamic changes during tracheal extubation. Compared with remifentanil alone, administration of dexmedetomidine in combination with remifentanil is effective in relieving cough and hemodynamic changes without inhibition of respiration. The purpose of this study was to investigate the effect of dexmedetomidine on the remifentanil concentration for the cough suppression during anesthetic emergence using the modified up-and-down method.

Study Timeline

• Study First Submitted: 2018-08-06
• Study First Submitted QC: 2018-08-06
• Study First Posted: 2018-08-09
• Study Start: 2018-08-16
• Primary Completion: 2019-03-22
• Study Completion: 2019-03-27
• Status Verified: 2020-01
• Last Update Submitted: 2020-01-06
• Last Update Posted: 2020-01-09

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 48

Inclusion Criteria

• ASA physical status I or II undergoing endoscopic sinus surgery or septoplasty under general anesthesia

Exclusion Criteria

• predicted difficult airway
• body mass index > 35 kg/m2,
• recent upper respiratory infection
• asthma
• current smoker
• patients using angiotensin converting enzyme-inhibitors
• uncontrolled hypertension

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Dexmedetomidine	Dexmedetomidine	Dexmedetomidine was infused before end of surgery and remifentanil was maintained at predetermined effect-site concentration during the emergence period
Dexmedetomidine	Remifentanil	Dexmedetomidine was infused before end of surgery and remifentanil was maintained at predetermined effect-site concentration during the emergence period
Remifentanil	Remifentanil	Normal saline was infused before end of surgery and remifentanil was maintained at predetermined effect-site concentration during the emergence period
Remifentanil	Normal saline	Normal saline was infused before end of surgery and remifentanil was maintained at predetermined effect-site concentration during the emergence period

Primary Outcome Measures

Name	Time	Method
Number of cough	from end of surgery to 5 min after tracheal extubation]	Number of cough or a strong and sudden contraction of the abdomen during periextubation periextubation periods

Trial Locations

Locations (1)

Ajou University Hospital; 🇰🇷 Suwon, Gyeongki-do, Korea, Republic of