Een gerandomiseerde placebo gecontroleerde studie naar de toegevoegde waarde van D-cycloserine aan exposure therapie bij pati??nten met een poststraumatische stress stoornis
- Conditions
- emotional processing of a traumatic eventflashbacks10002861
- Registration Number
- NL-OMON31376
- Lead Sponsor
- GGZ Nijmegen (Nijmegen)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 100
Inclusion criteria are (1) age between 18 and 65 and (2) current DSM-IV diagnosis of PTSD established with a structured diagnostic interview (M.I.N.I. and CAPS).
Diagnostic exclusion criteria are (1) psychosis or delusion disorders (current or in the past) (2) suicidality (3) mental retardation (4) substance abuse or dependence or alcohol abuse of dependence, as established by a structured diagnostic interview (M.I.N.I.). Medical exclusion criteria are (1) pregnant or lactating women. Also women who are planning a pregnancy and don???t want to postpone a pregnancy during the treatment phase are excluded. According to the Informatorium Medicamentorum (2006), the influence of the use of D-cycloserine during pregnancy and breastfeeding is unknown. However, for safety reasons, we exclude these women. (2) patients who have a serious and unstable medical illness, as confirmed by their doctor, such as use of a pacemaker, renal disease or porfyrie (3) a history of epileptic seizures (4) medication use that may interfere with D-cycloserine, such as anticoagulants (5) patients who use antidepressants
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method