NCT00596986Unknown不适用
Impact of Therapeutical Strategies on Emotional Processing in Depression: Neurofunctional and Clinical Issues in the Context of Affective Bias
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Neuroimaging Data (fMRI)
研究概览
简要总结
The purpose of this study is to determine how psychotherapy and pharmacotherapy respectively change brain activity in patients suffering from chronic depression.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Chronic Depression (Double Depression, Chronic MDE, MDE with incomplete remission)
- •HAMD-24>20
排除标准
- •Concurrent Psychotherapy or Psychopharmacotherapy
- •Previous Non-Response to Duloxetine
- •Non-Response to three Antidepressants of two different groups given at adequate doses or Non-Response to two empirically tested forms of Psychotherapy in the current Depressive Episode
- •Serious Psychiatric comorbidity
- •Serious Neurologic comorbidity
- •Contraindications to Duloxetine
- •Contraindications to fMRI
研究组 & 干预措施
PT
Active Comparator
Psychotherapy (CBASP) - Cognitive Behavioural Analysis System of Psychotherapy
干预措施: Cognitive Behavioural Analysis System of Psychotherapy (Behavioral)
AD
Active Comparator
Antidepressant Duloxetine
干预措施: Duloxetine (Drug)
结局指标
主要结局
Neuroimaging Data (fMRI)
时间窗: Before and After Therapy
次要结局
- HAMD(Weekly)
- Salivary Cortisol(Before and After Therapy)
研究者
研究点 (1)
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