Impact of Therapeutical Strategies on Emotional Processing in Depression: Neurofunctional and Clinical Issues in the Context of Affective Bias

Charite University, Berlin, Germany1 site in 1 country30 target enrollmentOctober 2008

ConditionsChronic Depression

InterventionsCognitive Behavioural Analysis System of Psychotherapy Duloxetine

DrugsDuloxetine

Overview

Phase: N/A
Intervention: Cognitive Behavioural Analysis System of Psychotherapy
Conditions: Chronic Depression
Sponsor: Charite University, Berlin, Germany
Enrollment: 30
Locations: 1
Primary Endpoint: Neuroimaging Data (fMRI)
Last Updated: 16 years ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study is to determine how psychotherapy and pharmacotherapy respectively change brain activity in patients suffering from chronic depression.

Registry

clinicaltrials.gov

Start Date

October 2008

End Date

September 2009

Last Updated

16 years ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Charite University, Berlin, Germany

Eligibility Criteria

Inclusion Criteria

•Chronic Depression (Double Depression, Chronic MDE, MDE with incomplete remission)
•HAMD-24\>20

Exclusion Criteria

•Concurrent Psychotherapy or Psychopharmacotherapy
•Previous Non-Response to Duloxetine
•Non-Response to three Antidepressants of two different groups given at adequate doses or Non-Response to two empirically tested forms of Psychotherapy in the current Depressive Episode
•Serious Psychiatric comorbidity
•Serious Neurologic comorbidity
•Contraindications to Duloxetine
•Contraindications to fMRI