Acetylcysteine in the Prevention of Renal Failure After Bypass Surgery
- Conditions
- Kidney Failure
- Registration Number
- NCT00211653
- Lead Sponsor
- Minneapolis Veterans Affairs Medical Center
- Brief Summary
The purpose of this study is to determine if Acetylcysteine is effective in preventing renal failure associated with cardiac surgery
- Detailed Description
Postoperative renal dysfunction is a predictor of significant morbidity and mortality among patients undergoing cardiac surgery. The mortality associated with coronary artery by-pass surgery increases from 2% to almost 19% in patients with renal failure and approaches 60% in patients who require hemodialysis. Patients with preoperative renal dysfunction referred for coronary artery by pass surgery have an extraordinarily high risk of requiring postoperative dialysis. For example, among those patients with preoperative creatinine \>2.5 mg/dL, almost 50% require hemodialysis.
Comparison: N-Acetylcysteine is superior to placebo in preventing renal failure after cardiac surgery
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 102
- Pts with baseline chronic kidney disease (eGFR<60 ml/min/1.73m2)undergoing cardiac surgery
- Patients on hemodialysis preoperatively
- IV contrast within 4 days prior to surgery
- Urgent/emergent surgery
- History of renal transplantation
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Rise in creatinine above baseline 7 days postoperatively
- Secondary Outcome Measures
Name Time Method Creatinine increase >25% or =/> 0.5 mg/dl above baseline Postoperative days 5, 7 and 30 Length of stay in the ICU and the hospital Operative mortality 30-day
Trial Locations
- Locations (1)
Veterans Affairs Medical Center
🇺🇸Minneapolis, Minnesota, United States