Non-invasive Response Assessment of Neo-adjuvant Chemotherapy in Gastric Cancer Patients Based on Circulating Exosomal LncRNA-GC1
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 700
- 试验地点
- 1
- 主要终点
- Detection of levels of circulating exosomal lncRNA-GC1
研究概览
简要总结
The investigators hope that through the analysis and research to find determine whether lncRNA-GC1 could serve as a non-invasive biomarker for monitoring the neo-adjuvant chemotherapy response for personalized medicine for gastric cancer.
详细描述
The LncRNA-GC1could noninvasively track dynamics of tumor burden and has been proposed as a real-time biomarker that can provide both predictive and prognostic values. But the value in monitoring the neo-adjuvant chemotherapy response is unclear. The investigators hope that through the analysis and research to find determine whether lncRNA-GC1 could serve as a monitoring biomarker for patients with gastric cancer receiving neo-adjuvant chemotherapy.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Having signed informed consent
- •Age≥ 18 years old
- •Histologically confirmed gastric adenocarcinoma
- •radiographically identified as advanced gastric cancer
排除标准
- •Other previous malignancy within 5 year
- •Surgery (excluding diagnostic biopsy) within 4 weeks prior to study
- •Pregnancy or lactation period
- •Legal incapacity
结局指标
主要结局
Detection of levels of circulating exosomal lncRNA-GC1
时间窗: Through study completion, an average of 1 year
Levels of circulating exosomal lncRNA-GC1 are detected by RT-PCR
次要结局
未报告次要终点
研究者
Lin Chen
Director of Department of General Surgery, Chinese PLA General Hospital
Chinese PLA General Hospital