Preventive and Personalized Medicine (2021-2023)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- number of SNPs associated with Heart Attack
研究概览
简要总结
This is a GWAS study that aims to identify possible candidate genes associate to heart attack by exploring single nucleotide polymorphism (SNP) in a group of heart attack, in the Kazakh population. The investigators hypothesize that the careful phenotyping of the subject sand matching with increase the power to find SNP significantly associate with heart attack
详细描述
A genome-wide association study (GWAS) is an approach used in genetics research to associate specific genetic variations with particular diseases. The method involves scanning the genomes from many different people and looking for genetic markers that can be used to predict the presence of a disease. Once such genetic markers are identified, they can be used to understand how genes contribute to the disease and develop better prevention and treatment strategies.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Persons of Kazakh nationality
- •Age up to 59 years inclusive at the time of primary myocardial infarction
- •Myocardial infarction was established in accordance with the EOC criteria: An increase and / or decrease in the level of cardiac troponin must be combined with at least one of the following: • Symptoms of myocardial ischemia • Newly occurring ischemic changes on the ECG • The appearance of a pathological Q wave • Identification according to imaging data methods of new areas of non-viable myocardium, or new areas of local contractility disorders of presumably ischemic etiology • Detection of a thrombus in the coronary arteries according to coronary angiography
- •Presence of coronary angiography
- •Persons able and willing to provide written informed consent;
排除标准
- •Age at primary myocardial infarction 60 years and older
- •Heart defects, congenital and acquired
- •Non-ischemic cardiomyopathies
- •Autoimmune diseases
- •Diabetes mellitus at the time of development of primary myocardial infarction
- •Terminal stages of renal and hepatic failure
结局指标
主要结局
number of SNPs associated with Heart Attack
时间窗: 1 year
Using GWAS to identify candidate genes associate with Heart Attack
次要结局
未报告次要终点
研究者
Ildar Fakhradiyev
Head of the Laboratory of Experimental Medicine
Asfendiyarov Kazakh National Medical University