Characteristics of Subjects With Overweight or Obesity at the Onset of Hypertension
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Thyroid hormones (FT3, FT4)
研究概览
简要总结
The study aims to investigate the characteristics of subjects with hypertension at onset among a cohort of apparently healthy subjects, with overweight or obesity (BMI ≥ 25 Kg / m2), and free of any drug treatment at the baseline. The evaluation includes anthropometric (weight, height, BMI, waist circumference), haematochemical (hormones, metabolic and routine) parameters and the screening for hypertension with ABPM. The diagnosis of hypertension is made in accordance with the 2017 guidelines of the American College of Cardiology / American Heart Association ACC / AHA.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 35 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Overweight or obesity (BMI> 25 Kg/m2)
排除标准
- •Any kind of drug
- •Hypertension
- •Endocrine diseases (diabetes mellitus, hypo or hyperthyroidism, hypopituitarism, etc.),
- •Chronic inflammatory diseases
- •Renal failure
- •Liver failure
- •Angina pectoris
- •Myocardial infarction and heart failure
- •Genetic heart diseases
- •Thrombocytopenias
结局指标
主要结局
Thyroid hormones (FT3, FT4)
时间窗: At baseline
FT3 (pg/mL), FT4 (pg/mL) concentration in serum
HDL cholesterol
时间窗: At baseline
HDL cholesterol (mg/dL) concentrations in serum
eGFR (estimated glomerular filtration rate)
时间窗: At baseline
eGFR (ml/min/1.73 mq)
Uric acid
时间窗: At baseline
Uric acid (mg/dL) concentration in serum
Potassium
时间窗: At baseline
Potassium (mmol/L) concentration in serum
Creatinin
时间窗: At baseline
Creatinin (mg/dl) concentration in serum
Total cholesterol
时间窗: At baseline
Total cholesterol (mg/dL) concentrations in serum
LDL cholesterol
时间窗: At baseline
LDL cholesterol (mg/dL) concentrations in serum
Insulin
时间窗: At baseline
Insulin (mIU/L) concentration in serum
Triglycerides
时间窗: At baseline
Triglycerides (mg/dL) concentrations in serum
TSH
时间窗: At baseline
TSH (mU/L) concentration in serum
Sodium
时间窗: At baseline
Sodium (mEq/L) concentration in serum
次要结局
- Weight(At baseline)
- BMI(At baseline)
- Height(At baseline)
研究者
Gianluigi Giannelli
Clinical Professor
Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis