Evaluation of analgesic effects of intravenous metoclopramide versus intravenous ketorolac in patients with primary acute headache

Phase 3

Completed

• Conditions: Condition 1: Migraine. Condition 2: Tension-type headache. Condition 3: Cluster headaches.; Migraine; Tension-type headache; Cluster headaches and other trigeminal autonomic cephalgias (TAC); G44.2; G44.0

• Registration Number: IRCT20151103024853N4
• Lead Sponsor: Ahvaz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 7 September 2020

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 98

Inclusion Criteria

Patients referring to the emergency department with acute primary headache (migraine, tension, cluster)
Age: minimum 18 years old and maximum 65 years old

Exclusion Criteria

Pregnancy
Nursing mothers
Any active bleeding
CHF (Congestive Heart Failure)
MI (Myocardial Infarction) history
Parkinson or history of any Extrapyramidal Side Effects
Pheochromocytoma
Epilepsy and history of seizure
History of Depression
Allergy to experimented drugs
Painkillers administration before admission to the Emergency Department (ED)
??Systolic Blood pressure under 90mmHg or above 180mmHg
Heart rate under 50 beats/min or above 150 beats/min
Patients taking Antipsychotics, Promethazine, MAO inhibitors, Rivastigmine

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pain Visual Analogue Scale (VAS Scoring). Timepoint: Baseline, 15, 30, 60 minutes after intervention. Method of measurement: 10-cm visual analog pain scale.

Secondary Outcome Measures

Name	Time	Method
Patients achieved headache freedom in the ED without requiring rescue medication. Timepoint: 60 minutes after intervention. Method of measurement: Patients own statement of Headache freedom.;Patients that required rescue medication in the ED. Timepoint: 60 minutes after intervention. Method of measurement: Minor headache improvement in patients with the discretion of the treating physician.