TEA, ESB and Paravertebral Block During Single-lung Ventilation for Lung Resection

Not Applicable

Recruiting

• Conditions: Lung Diseases; Pain, Acute
• Interventions: Procedure: Thoracic epidural anesthesia; Procedure: erector spinae block; Procedure: paravertebral block anesthesia

• Registration Number: NCT05211791
• Lead Sponsor: South Egypt Cancer Institute

Brief Summary

Thoracotomy operations are known to be painful surgical procedures, so providing effective intraoperative and postoperative analgesia is so important for all anaesthesiologists. Ineffective pain management interferes with deep breathing, coughing, and remobilization resulting in atelectasis and pneumonia.

Ultrasound-guided ESP block is a myofascial plane block that provides analgesia for thoracic or abdominal segmental innervation depending on the level of the injection site. Thoracic epidural analgesia (TEA) is considered the gold standard analgesic technique for thoracic surgeries. But the invasiveness of this technique, the rare but serious neurologic complications and the failure rates up to 30% are the disadvantages of epidural analgesia

Detailed Description

The aim of this study is to compare the effect of different blocks as TEA, erector spinae block or paravertebral block on improving peri-operative analgesia and post-operative outcome in pulmonary resection in adult patients.

Study Timeline

• Study First Submitted: 2022-01-02
• Study Start: 2022-01-10
• Study First Submitted QC: 2022-01-14
• Study First Posted: 2022-01-27
• Status Verified: 2023-05
• Last Update Submitted: 2023-05-07
• Last Update Posted: 2023-05-09
• Primary Completion: 2023-06-10
• Study Completion: 2023-10-20

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

• aged between 18 to 70 years old for elective lung resection. with American Society of Anesthesiology physical status (ASA-PS) I-III

Exclusion Criteria

• Total pneumonectomy
• Hepatic or renal dysfunction.
• contraindications for epidural anesthesia as Coagulopathy and neurological and spinal deficits.
• emergency cases

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group TEA	Thoracic epidural anesthesia	insertion of Thoracic epidural anesthesia plus GA with lung isolation using suitable size double lumen tube at level T6
Group ESB	erector spinae block	U/S guided erector spinae block anesthesia using 15 ml local anesthesia plus GA with lung isolation using a suitable size double-lumen tube
Group PVB	paravertebral block anesthesia	U/S guided paravertebral block anesthesia using 15 ml local anesthesia as total volume plus GA with lung isolation using suitable size double lumen tube

Primary Outcome Measures

Name	Time	Method
peri-operative analgesia	up to 48 hours postoperative	Visual Analogue score (resting and during cough) from 0 (no pain) to 10 (worst pain pain measurement

Trial Locations

Locations (1)

South Egypt Cancer Institute, Assiut University, Arab Republic of Egypt; 🇪🇬 Assiut, Egypt