Long-term Prognosis of Cluster Headache: a Retrospective Cohort Study
试验速览
- 阶段
- 不适用
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- overall prognosis
研究概览
简要总结
Cluster headache is a syndrome characterized by disabling headache and accompanying autonomic symptoms. Despite cluster headache is called "suicide headache", its natural history has not been well investigated. The investigators aimed to investigate its disease course, overall prognosis, and treatment pattern in retrospective cohort.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who were diagnosed as cluster headache
- •More than 5 years after the first visit
排除标准
- •Subjects who refused the telephone visit
结局指标
主要结局
overall prognosis
时间窗: at least 5 years after the first visit
active disease: at least one bout within the past 5 years Remission: no headache for 5 years and twice of the usual remission period
Changes in the length of active/inactive periods
时间窗: at least 5 years after the first visit
Changes in seasonal and diurnal predilections
时间窗: at least 5 years after the first visit
Changes in autonomic symptoms
时间窗: at least 5 years after the first visit
Changes in treatment responses
时间窗: at least 5 years after the first visit
次要结局
- Any depression(at least 5 years after the first visit)
- Any suicidal thoughts (active/passive), plans, and attempts(at least 5 years after the first vis)
研究者
Chin-Sang Chung
MD, PhD, Professor of neurology
Samsung Medical Center