Treatment of Complex Regional Pain Syndrome type 1: a randomised, double-blind, placebo-controlled study with S(+)-ketamine

eiden University Medical Centre (Netherlands)0 个研究点目标入组 60 人开始时间: 2006年1月9日最近更新: 2015年1月13日

试验速览

暂无简介。

•Patients will be male or female adult patients with a clinical diagnosis of CRPS 1 who are referred to the pain centre outpatients' clinic of the department of Anaesthesiology at the LUMC.
•1. Patients should fulfill the diagnostic criteria of the consensus report of CRPS 1:
•1.1. Continuing pain, allodynia or hyperalgesia, in which the pain is disproportionate to any inciting event
•1.2. Evidence at some time of edema, changes in skin blood flow or abnormal sudomotor activity in the region of the pain
•1.3. No condition that would otherwise account for the degree of pain and dysfunction
•2. Patients must report a VAS-spontaneous pain score of 5 cm or higher
•3. Patient's age is between 18 and 70 years
•4. Onset of symptoms must be shorter than 6 months or longer than 3 years before inclusion
•5. Patients should give a written informed consent

•1. Patients who are not able to give informed consent
•2. Patients suffering from other pain syndromes, interfering with pain ratings
•3. Patients suffering from other syndromes interfering with pain ratings
•4. Patients suffering from a kidney and/or severe liver disease
•5. Patients suffering from nerve damage in the affected area
•6. Patients with an active infection
•7. Patients with high intracranial pressure
•8. Patients with epilepsy
•9. Patients with a psychiatric illness
•10. Patients with thyroid disease
•11. Patients with cancer
•12. Patients with cardiac disease
•13. Patients with pulmonary disease
•14. Patients with glaucoma
•15. Patients with a history of cerebral vascular accident (CVA)
•16. Patients who are a pregnant
•17. Strong-opioid consumption (step one and two of the WHO pain ladder is allowed)

发起方

eiden University Medical Centre (Netherlands)