Light Treatment for Sleep/Wake Disturbances in Alzheimer's Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Sleep Initiation and Maintenance Disorders
- Sponsor
- Stanford University
- Enrollment
- 118
- Locations
- 1
- Primary Endpoint
- Total Sleep Time
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
The aim of this study is to demonstrate the efficacy of timed exposure to bright light for the treatment of disturbed nighttime sleep and daytime wake in community-dwelling dementia patients and their caregivers, and to determine if there are genetic relationships between memory problems and sleep problems
Detailed Description
1. Efficacy: Up to 4 weeks of morning bright light exposure will be more efficacious than morning dim light in consolidating nighttime sleep as assessed by actigraphy. 2. Predictors of response: We expect the primary predictor of treatment response will be initial MMSE score. Secondary predictors include baseline sleep/wake and circadian parameters and age. 3. Effectiveness: Bright light treatment will be more effective than dim light in improving quality of life. 4. An understanding of some of the genetic markers of memory and/or sleep problems.
Investigators
Jerome A Yesavage,
Professor of Psychiatry
Stanford University
Eligibility Criteria
Inclusion Criteria
- •Alzheimer's Disease Patients:
- •Stanford Alzheimer's Disease Core Center member or potential member, with diagnostic criteria met for probable AD, living with caregiver willing to participate in the protocol
- •Non-institutionalized
- •Caregivers:
- •Living in home of AD patient and willing to participate in protocol
Exclusion Criteria
- •Alzheimer's Disease Patients:
- •History of manic or bipolar disorder
- •Prior bright light treatment
- •Irregular or non-24 hour sleep/wake cycle
- •Positive result on multi-staged RLS/PLMD
- •Medical/Ophthalmologic Exclusions
- •RDI \>20 on overnight EdenTrace® recording
- •Caregivers:
- •History of manic or bipolar disorder
- •Medical/Ophthalmologic Exclusions
Outcomes
Primary Outcomes
Total Sleep Time
Time Frame: 2 weeks
The amount of actual sleep time in a sleep episode.
Secondary Outcomes
- WASO (Wake After Sleep Onset)(2 weeks)