Evaluation of effect of thyroid hormone therapy on prognosis of patients with traumatic brain injury
Phase 3
Recruiting
- Conditions
- S06.2Diffuse traumatic brain injury.Diffuse traumatic brain injury
- Registration Number
- IRCT20130310012776N6
- Lead Sponsor
- Vice chancellor of research. Shiraz University of medical sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 266
Inclusion Criteria
Pure moderate-to-severe TBI (GCS: motor score < 6)
Low normal TFT profile: T3 & T4 in first 25% of normal range
normal range of TSH
Exclusion Criteria
Mild traumatic brain injury
Patients with a pituitary abnormality on pituitary imaging
Patients who were unwilling to participate in the study or had not completed their investigations
History of Hyperthyroidism or hypothyroidism
History of thyroid hormone therapy
History of thyroid surgery
Glasgow coma scale=3 & Glasgow coma scale=4 with fixed pupils
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ICU length of stay. Timepoint: Since the time of trauma to discharge from the hospital. Method of measurement: Day.
- Secondary Outcome Measures
Name Time Method Glasgow outcome scale extended. Timepoint: Three & six month after traumatic brain injury. Method of measurement: Glasgow outcome scale extended.