Generation of Haploid Stem Cells From Human Germ Cells
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Rambam Health Care Campus
- Enrollment
- 10
- Locations
- 2
- Primary Endpoint
- Patients donated samples
Study Overview
Brief Summary
Human cells are diploid (contain a double set of chromosomes). The diploid genome is complex and therefore limits genetic research approaches in biomedical models. To overcome this problem experimental generation of haploid stem cells has been done in animals. The investigators aim at generating haploid stem cells from human germ cells that are a useful tool in genetic research and screening.
Detailed Description
Human cells are diploid (contain a double set of chromosomes). The diploid genome is complex and therefore limits genetic research approaches in biomedical models. To overcome this problem experimental generation of haploid stem cells has been done in animal models. haploid cells are easier for genetic manipulations, such as knock-in and knock-out of genes, and therefore should make a better experimental model. The investigators aim at generating haploid stem cells from human haploid germ cells.
Study Design
- Study Type
- Observational
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 50 Years (Adult)
- Sex
- Male
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •males over the age of 18 and under 50
- •no known chronic illness
- •not taking any chronic drugs
Exclusion Criteria
- •males under 18 or over 50
- •any known chronic illness
- •taking chronic medications
Outcomes
Primary Outcomes
Patients donated samples
Time Frame: June 2011-November 2013
No samples collected to date
Secondary Outcomes
- No secomdary outcome(June 2011 - November 2013)